We will introduce why and how we are at point of controversies today. The opening debate will explore whether a genetic-driven approach just needs more time to produce results or whether we need to ﬁrst invest more in a regulatory ﬁltering of genetic variations.
WELCOME FROM SUMMIT CHAIRPERSON
Director, Tel Aviv University Cancer Biology Research Center, Tel Aviv, Israel
Chair of the Board of Directors and Scientific Director of the Max Delbrück Center for Molecular Medicine in the Helmholtz Association Member of the Board of Directors of the Berlin Institute of Health (BIH), Berlin, Germany
Director, Clinical Research Unit, RLUH, Liverpool, UK
|Same Medicine, Different Results - the Impact of Personalised Medicine |
The talk will highlight the origins and rationale behind personalised medicine, its current reach and the potential for personalised medicine to transform the way care is delivered to patients over the next two decades.
of Cardiovascular Physiology, Oxford, UK
Regulatory Filtering of Genetic Variation: Why GWAS Outcomes so far are Disappointing
The influence of variations in DNA sequences on the phenotype is strongly filtered by regulatory networks at higher levels (cells, tissues, organs, systems). This is the main reason why GWAS research has produced relatively disappointing outcomes in terms of correlations with health and disease. It is now far from certain that extending such studies to much larger cohorts will solve the problem. The solution may be to switch to understanding better the filtering by regulatory networks.
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